Resource Material

The resource articles that I have read and provided on this site, are solely intended to assist you in your own research journey. They are not endorsed or a legal claim of mine or Sage Essentials. Scroll down the page for specific articles for medical conditions.

If you would like an in-depth understanding or history of Cannabinoids (CBD), watch Dr. Raphael Mechoulam “Godfather of Cannabis” videos. He is an Israeli organic chemist and professor of Medicinal Chemistry and has been studying cannabinoids for over 50 years.

Dr. Raphael Mechoulam PH.D – (The Scientist) Click for Videos

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What are some of the benefits of CBD?

World Health Organization (WHO) Cannabidiol (CBD) Pre-Review Report (Pg. 18)

Table 1. Overview of diseases for which CBD may have therapeutic benefits taken from Pisanti et al (2017) [69]

Disease	Effects
Alzheimer’s disease	Ant-inflammatory, antioxidant, antiapoptotic in in vitro and in vivo models of Aβ-evoked neuroinflammatory and neurodegenerative responses.
Parkinson’s disease	Attenuation of the dopaminergic impairment in vivo; neuroprotection; improvement of psychiatric rating and reduction of agitation, nightmare and aggressive behavior in patients. Multiple
Multiple sclerosis	Improved signs of EAE in mice, ant inflammatory and immunomodulatory properties
Huntington’s disease	Neuroprotective and antioxidant in mice transgenic models; no significant clinically important differences in patients.
Hypoxia-ischemia injury	Short term neuroprotective effects; inhibition of excitotoxicity, oxidative stress and inflammation in vitro and in rodent models.
Pain	Analgesic effect in patients with neuropathic pain resistant to other treatments.
Psychosis	Attenuation of the behavioral and glial changes in animal models of schizophrenia; anti-psychotic properties on ketamine-induced symptoms
Anxiety	Reduction of muscular tension, restlessness, fatigue, problems in concentration, improvement of social interactions in rodent models of anxiety and stress; reduced social anxiety in patients.
Depression	Anti-depressant effect in genetic rodent model of depression.
Cancer	Antiproliferative and anti-invasive actions in a large range of cancer types; induction of autophagy-mediated cancer cell death; chemo preventive effects.
Nausea	Suppression of nausea and conditioned gaping in rats
Inflammatory diseases	Ant-inflammatory properties in several in vitro and in vivo models; inhibition of inflammatory cytokines and pathways
Rheumatoid arthritis	Inhibition of TNF-α in an animal model
Infection	Activity against methicillin-resistant Staphylococcus aureus
Inflammatory bowel and Crohn’s diseases	Inhibition of macrophage recruitment and TNF-α secretion in vivo and ex vivo; reduction in disease activity index in Crohn’s patients
Cardiovascular diseases	Reduced infarct size through anti-oxidant and anti-inflammatory properties in vitro and in vivo
Diabetic complications	Attenuation of fibrosis and myocardial dysfunction